For the first time, intestinal inflammation is believed to have been traced to systemic chromosome damage in rodents. This administered link may further lead to the early detection and cure of inflammatory disorders in human beings. This association between intestinal inflammation and systemic chromosome damage in mice was done by the University of California, Los Angeles (UCLA) scientists.
Seemingly inflammatory diseases may be associated with certain lymphomas and cancers of the liver, colorectal and abdominal. Therefore it is believed that an early detection of inflammation may be able to ensure a quick treatment which may in turn reduce the potential cancer-causing damage. Evidently, in the peripheral circulating blood, the chromosome damage may be used as an indicator of intestinal inflammation prior to the occurrence of any symptoms.
Senior study author, Robert Schiestl, scientist at Jonsson Cancer Center, UCLA, says that, “This was not known before, that intestinal inflammation causes damage that can be found throughout the body. This may help explain how inflammation leads to these cancers.”
These experts could evidently recognize the chromosome damage in the blood of the animal models even before the visibility of colitis in them. These animal models were stated to have been manipulated to develop inflammatory disorder.
The study investigators believe that this test may be able to substitute the need for conducting an invasive endoscopic exam for the early identification of inflammatory diseases. It is presumed that the early identification may in turn aid in reducing the inflammation which may further prevent the occurrence of cancer. Seemingly a clinical trial has been launched to test these results in human subjects as well.
These findings have been published in the issue of the Cancer Research, which is a peer-reviewed journal of the American Association for Cancer Research.