Periodontitis known as an oral infection progressively destroys periodontal tissues resulting in tooth loss. Most present day therapies are apparently unable to repair tooth-supporting defects and regaining tissues lost in periodontitis. A team of experts have now introduced fibroblast growth factor-2 (FGF-2) in periodontal regenerative therapy which seems to be safe as well as effective for treating the oral infection.
Researchers undertook a randomized, double-masked, placebo-controlled clinical trial on 253 adults afflicted with periodontitis. In the process of periodontal surgery, M. Kitamura, from Osaka University Graduate School of Dentistry, Japan, and colleagues randomly administered one among the three different doses of FGF-2 to localized bone defects. All the doses of FGF-2 presumably displayed dramatic superiority over the standard of care, in which the vehicle alone was 0.01 for the percentage of bone fill at 36 wks after administration. This percentage seemingly reached the highest point in the mid-dose FGF-2 group. If the scientists are to be believed then, application of FGF-2 can be significantly helpful in human periodontal tissue regeneration destroyed by periodontitis.
The research is published in the International and American Associations for Dental Research’s Journal of Dental Research.