Kaiser Permanente LogoSkin cancer is said to be a malignant development on the skin. As opposed to preceding assumptions, the application of non-steroidal anti inflammatory drugs may not be linked to the threat of squamous cell skin cancer. At least this is what a study claims.

Non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin, ibuprofen and celecoxib decrease pain and inflammation by obstructing an enzyme caught up in generating inflammatory compounds. This was provided as background information. NSAIDs may also restrain the growth of cancer cells by provoking cells to die and decelerating the development of new blood vessels.

Laboratory studies of cells and animals appear to have specified that NSAIDs guard against squamous cell carcinomas, general kinds of cancers that materialize in the upper layers of the skin. Nevertheless, while studies have assessed the connections between NSAIDs and other kinds of cancers counting colorectal, breast, prostate and lung, not many seem to have evaluated the alliance between NSAID use and squamous cell carcinoma danger in human populations.

Maryam M. Asgari, M.D., M.P.H., of Kaiser Permanente Northern California, Oakland, and colleagues assessed about 415 health plan members who were detected with squamous cell carcinoma in 2004 and roughly 415 control patients who were of the same age, sex and race but seemed to have no past record of skin cancer. Subjects apparently finished a survey about NSAID use, 10 years before.

Approximately 61 percent accounted for frequent use of NSAIDs in the preceding ten years, counting 48 percent who consumed aspirin, around 18 percent who used ibuprofen, about 5 percent who took naproxen and roughly 4 percent who consumed nabumetone.

The authors commented, “Regular use of any NSAID was not associated with a reduction in squamous cell carcinoma risk. Although NSAID users whose exposure was of short duration (one to three years) appeared to be at somewhat increased risk for squamous cell carcinoma, we found no consistent effects of duration of use of any NSAID on squamous cell carcinoma risk. Given the potential toxic effects of NSAIDs, including platelet dysfunction and gastric ulcers, more uniformly efficacious chemopreventive agents with safer adverse effect profiles need to be explored.”

Supposedly, Squamous cell carcinoma threat also did not seem to vary irrespective of NSAID dose, whether the medications were taken by a pharmacy nor with any individual kind of NSAID medication.

The study was published in the Archives of Dermatology, one of the JAMA/Archives journals.