Scientists seem to be working extremely hard everyday to find out new causes of the lethal and devastating disease cancer. Well, they appear to have found one more cause. Scientists from Yale Cancer Center and other institutions claim to be the first to show how dissimilar groups of cells from the same tumor could develop into tumors.
The researchers apparently produced new mouse models of melanoma to examine dissimilarities between cells in the same tumor. By means of stem cell markers, the scientist could split tumor cells into three different groups. One group of cells constantly developed into tumors following injection of a single cell. The second group is said to occasionally form tumors and the third group of cells is believed to seldom develop into tumors.
The research team, headed by Marcus Bosenberg, M.D., Ph.D., lead author and associate professor of dermatology and pathology at Yale School of Medicine, commented, “This is the only time a research group has been able to take individual cells from a cancer and determine that one will definitely form a tumor and the other will not. This detailed analysis will help us to develop more effective treatment options for our patients and may explain why some patients have a partial-response to treatment.â€
These outcomes are claimed to be the first to exhibit elevated rates of tumor development after the injection of single purified cells. Till now, laboratories have supposedly tried to distill cells, supposedly capable of reforming tumors in mouse models but usually require around 100-100,000 purified cells, which is said to have decelerated the examination procedure.
The capability to filter the particular cancer-causing cells in a tumor may perhaps enable for a more inclusive assessment of the molecular features that apparently describe tumor-forming ability and resistance to chemotherapy.
The findings appear in the Journal Cancer Research.