Professionals believe that inflammation is the culprit behind all forms of metabolic diseases like cardiovascular disorders and diabetes. A team of professionals from the UC Davis Health System has disclosed an apparent causal factor for metabolic syndromes.
In the study, nearly 90 persons in the age-group 21 to 70 and suffering from issues such as obesity, hypertension or high cholesterol levels were included. As per the outcomes, individuals who suffered from metabolic issues seemed to possess higher proportions of messenger RNA and cell-surface receptors namely TLR2 and TLR4. They also appeared to carry high amounts of the master inflammatory switch along with cytokines.
According to the scientists, not all obese people suffer from metabolic syndromes. The aforesaid effects are the result of a metabolic-syndrome environment. Individuals affected by metabolic issues also manifested larger proportions of fatty acids and gram-negative bacteria namely endotoxin.
The investigators claimed that Toll-like sentinel proteins may be accelerating the inflammatory activity seen in people suffering from metabolic complications. These TLR2 and TLR4 receptors supposedly accelerated the production of cytokines in the body, which play a primary role in inflammation. The team urged people to suppress TLR activity by means of weight loss and other medications used for the treatment of heart disease and diabetes.
The report is published in the February 22 issue of the journal, Diabetes Care.